Genetic selection of growth-inhibitory sequences in mammalian cells.
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متن کاملPositive selection of growth-inhibitory genes.
We have isolated a limited set of cDNAs that limit cell proliferation using a unique assay based on the dilution of a lipophilic fluorescent dye as transfected cells divide. The identification of growth-inhibitory factors has been limited by the lack of a strong assay for growth inhibitors. A growth-inhibited cell does not grow and so is at a selective disadvantage in vitro when compared with a...
متن کاملThe Artificial Production in Mammalian Plasma of Substances Inhibitory to the Growth of Cells
Active immunity to the growth of tissue may be obtained by intraperitoneal injections of tissue emulsions. This immunity is of short duration and is followed by an anti-immunity. The immunity varies for individual tissues both in extent and in the time of onset. The immunity is not specific in so far that it is not more marked to the tissue similar to that forming the emulsion.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.26.12549